difference between turner syndrome and klinefelter syndrome

Genotype 44 + X0 44 + XXY 2. Your email address will not be published. These 2 diseases are the most sex chromosome disorders characterized by one extra X in the SK male (47XXY) and the loss of an X in the girls with ST (45 X). His experience in communicating with the general public during his medical practice has enabled him to describe facts that a layman has to know about a particular disorder in a concise and understandable manner. Down syndrome typically is recognized at birth, Turner syndrome often is not recognized until adolescence,and many men with Klinefelter syndrome are never diagnosed. Additionally, Turner syndrome and Klinefelter syndrome present similar symptoms. PMID: 26999880 [PubMed - indexed for MEDLINE] 6. 1.Kumar, Vinay, Stanley Leonard Robbins, Ramzi S. Cotran, Abul K. Abbas, and Nelson Fausto. Robbins and Cotran pathologic basis of disease. The early diagnosis of them can be helpful in treating the complications arising from the underlying disease. The two genetic disorders discussed here are extremely common conditions. Ranidu is passionate about writing articles on medical topics in general parlance. Kingery SE, Wintergerst KA. 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The main difference between Turner Syndrome and Klinefelter Syndrome is that Turner Syndrome is the change in the genetic chromosomes in females while a Klinefelter Syndrome is a change in ancestral chromosomes in men. Filed Under: Diseases Tagged With: Compare Klinefelter and Turner Syndrome, Klinefelter and Turner Syndrome Differences, Klinefelter and Turner Syndrome Relationship, Klinefelter Syndrome, Klinefelter Syndrome Clinical Features, Klinefelter Syndrome Definition, Klinefelter vs Turner Syndrome, Turner Syndrome, Turner Syndrome Clinical Features, Turner Syndrome Definition. Patients having the Klinefelter syndrome have an increased risk of developing breast cancers, extragonadal germ cell tumors and autoimmune diseases such as SLE. Klinefelter syndrome is a genetic condition that results when a boy is born with an extra copy of the X chromosome. Philadelphia, Pa: Elsevier Saunders, 2010. KLINEFELTER SYNDROME It is the state of male hypogonadism due to 2 or more X chromosome with 1 or more y chromosome. Undeveloped testes, sparse … In Kallmann syndrome the levels of LH and FSH are much lower than normal, known as hypogonadotropism. Terms of Use and Privacy Policy: Legal. Turner syndrome is the genetic abnormality of females while Klinefelter syndrome is a genetic abnormality of men. Down syndrome, Turner syndrome, and Klinefelter syndrome constitute the most common chromosomal abnormalities encountered by primary care physicians. Gene mutations are the alterations of the nucleotide sequence of a gene. Top 10 blogs in 2020 for remote teaching and learning; Dec. 11, 2020 2. Trisomy of sex chromosome (2n+1), in this XXY chromosome, are present in males. Turner and Klinefelter syndromes are common chromosomal disorders involving X chromosome.1,2 Turner syndrome is characterized by partial or complete absence of one X chro-mosome in women,1 and it occurs in 1:2,000 to 1:5,000 live female births.3 Klinefelter syndrome results from two or more X chromosomes in men.4 Klinefelter syndrome is one We report a comparative analysis of TS vs. KS regarding differences at the genomic network level measured in primary samples by analyzing gene expression, DNA methylation, and chromatin conformation. Turner syndrome is related to the X chromosome, which is one of the two sex chromosomes.People typically have two sex chromosomes in each cell: females have two X chromosomes, while males have one X chromosome and one Y chromosome.Turner syndrome results when one normal X chromosome is present in a female's cells and the other sex chromosome is missing or structurally altered. Hypogonadism – Plasma gonadotropin concentration (especially FSH concentration) is elevated. In Klinefelter syndrome you have partial to normal puberty but the testicles do not function correctly. 1. As previously mentioned, in a majority of the cases the Klinefelter syndrome is associated with the 47, XXY karyotype. What is Turner Syndrome (adsbygoogle = window.adsbygoogle || []).push({}); Copyright © 2010-2018 Difference Between. INCIDENCE : 1 in 2000 live male births KARYOTYPE: 82% have classical 47,XXY 15% mosaics , 46XY/47,XXY Remaining polysomic individuals 13. Mosaic Turner syndrome is when some, but not all of the cells of the individual having Turner’s syndrome have an unusual combination of sex chromosomes. This syndrome is found in 1 out of 1000 males. In the case of Klinefelter syndrome, the male has 2 X chromosomes and 1 Y chromosome (Figure 1). Testosterone therapy and hormone therapy. Klinefelter syndrome. Chromosomal Mutation: Klinefelter syndrome, Turner syndrome, and Down syndrome are caused by chromosomal mutations. What is the difference between Klinefelter syndrome and Triple X syndrome? Genetic Sex: XXY; generally female because of the presence of two X chromosomes. Since there is usually one additional chromosome in Klinefelter syndrome, it is considered as a trisomy while tuner syndrome is regarded as a monosomy because one chromosome is missing in the affected individuals. With Turner's Syndrome, the females actually have 1 less chromosome, not an extra one or sometimes only part of the X chromosome is missing. @media (max-width: 1171px) { .sidead300 { margin-left: -20px; } } “Human chromosomesXXY01” By User:Nami-ja – Own work (Public Domain) via Commons Wikimedia Blog. 1 INTRODUCTION. No. This condition is typically diagnosed after puberty because the testicular abnormality does not develop before the early puberty. The karyotype usually associated with the Turner syndrome is 45, X. Since the genes that produce "maleness" are on the Y chromosomes, these individuals will always be female. 1. Turner Syndrome occurs in a female fetus with an incomplete or missing X Chromosome, with characteristic features, Non-Verbal Learning Disabilities, short stature & infertility. The main difference between Klinefelter and Turner syndrome is that Klinefelter is a condition of trisomy in which one extra X chromosome is present in the genome of the person and Turner syndrome is a condition of monosomy in which one X chromosome is lacking in the genome of the affected person.There are many differences between Klinefelter syndrome and Turner syndrome although both … Klinefelter syndrome is a genetic condition affecting males, and it often isn't diagnosed until adulthood.Klinefelter syndrome may adversely affect testicular growth, resulting in smaller than normal testicles, which can lead to lower production of testosterone. Sex Characters Undeveloped ovaries and breasts, small uterus, absence of menstruation, absence of sex chromatin, narrow hips. There is a lot of variation in this regard, with some individuals having cells that are 45,X but in other cases they may even have some cells that are XY and some that are 45,X. Turner syndrome and the Klinefelter syndrome are the rare cases where the earlier one occurs in 1 out of 2500 phenotypic female, while the latter one occurs in 1 in 1100 births. Turner syndrome is the complete or partial monosomy of the X chromosome, which is characterized primarily by the hypogonadism in phenotypic females. Both are trisomies (when someone has three of a certain type of chromosome instead of two), but Klinefelter's is with XXY and Down syndrome is a trisomy of chromosome 21. Turner syndrome causes female hypogonadism. … In Klinefelter syndrome the levels of LH and FSH are higher than normal, known as hypergonadotropism. Adolesc Med State Art Rev. The X chromosome carries more genetic information than is present on the Y chromosome. It is due to trisomy (2n+1) of sex chromosome. 2. The presence of a Y chromosome is necessary for an individual to be male. After the merger, the newly formed three individual XXY sex chromosomes. Turner syndrome is the complete or partial monosomy of the X chromosome which is characterized primarily by the hypogonadism in phenotypic females. The main difference between Klinefelter and Turner Syndrome is that Klinefelter syndrome is a trisomy whereas Turner syndrome is a monosomy. Sex Sterile Female Sterile Male 3. When a boy is born with the different genetic condition than the normal one, where instead of having normal XY sex chromosome, they have XXY chromosomes, it is termed as Klinefelter syndrome. XO; genetically sexless. This condition is far less common than Klinefelter syndrome, affecting only one in 2,000 to 2,500 female births. Normally, males have 46 chromosomes with one X and 1 Y chromosome. Monosomy of sex chromosome (2n-1), in this only one X chromosome, is present. Often, symptoms are subtle and subjects do not realize they are affected. 2015 Aug;26(2):411-27. This is due to the non-disjunction during the meiotic division of germ cells of one of the parents. In the case of Turner’s syndrome have been X chromosome missing in the sex cell, or lost after the merger of male and female sex cells, but the reason why this happens is unknown. All rights reserved. Turner syndrome leads to various developmental problems and people with this syndrome are at risk of many diseases. In this condition, there is missin… The main difference between Klinefelter and Turner syndrome is that Klinefelter is a condition of trisomy in which one extra X chromosome is present in the genome of the person and Turner syndrome is a condition of monosomy in which one X chromosome is lacking in the genome of the affected person. It is commonly treated with estrogen, growth hormones and replacement therapy. Side by Side Comparison – Klinefelter vs Turner Syndrome in Tabular Form Turner syndrome can cause a variety of medical and developmental problems, including short height, failure of the ovaries to develop and heart defects.Turner syndrome may be diagnosed before birth (prenatally), during infancy or in early childhood. Turner syndrome is the dysgenesis in the female gonads, while Klinefelter syndrome is the male hypogonadism. Individuals with Turner syndrome have an X chromosome but no Y chromosome. In both Turner syndrome (TS) and Klinefelter syndrome (KS) copy number aberrations of the X chromosome lead to various developmental symptoms. Both these conditions are cytogenic disorders involving the sex chromosomes. Klinefelter syndrome is a trisomy, and the most frequently associated karyotype is 47, XXY. Individuals with Klinefelter syndrome have two X chromosomes but also have one Y chromosome. Privacy. Lack of secondary male sexual characteristics, No mental retardation but the IQ is slightly less than that of the normal population, Most severely affected individuals suffer from edema of the dorsum of hand and foot during infancy, Swelling of the nape of the neck can also be seen occasionally in the affected infants, Streak ovaries, infertility, and amenorrhea. KLINEFELTER’S SYNDROME 12. Anthropometric measures were height, sitting height, arm span, length of arm, hand, and foot, biacromial and bi-iliac diameter, hip, waist, and head circumference as well as 2D:4D digit ratio. Turner Syndrome and Klinefelter Syndrome. 4. Turner syndrome (TS) and Klinefelter syndrome (KS) are two of the most common sex chromosome aneuploidies (Berglund et al., 2019).The prevalence of TS is approximately 1 in 2000 to 1 in 4000 among women and is characterized by a chromosomal disorder affecting phenotypically female individuals harboring one intact X chromosome and complete absence [X … The syndrome may also cause reduced muscle mass, reduced body and facial hair, and enlarged breast tissue. Conversely, if Klinefelter syndrome obtain gametes (sperm or egg) two sex chromosomes. All measurements were performed by the same observer (AS). 1. Raven magnimeter and Harpenden anthropometer were u… 3. 5. Klinefelter's syndrome (KS) affects one in 600 men and Turner's syndrome (TS), one in 2500 women. Overview and Key Difference Turner syndrome. ADVERTISEMENTS: Some of the major Differences between Turner’s syndrome and Klinefelter’s Syndrome are as follows: Character Turner’s Syndrome Klinefelter’s Syndrome 1. Adolesc Med State Art Rev. Turner Syndrome and Klinefelter Syndrome. Klinefelter syndrome (KS), also known as 47,XXY is the set of symptoms that result from two or more X chromosomes in males. “45,X” (CC BY-SA 3.0) via Commons Wikimedia. This is because of the absence of an entire X chromosome, structural damages to the X chromosomes or the presence of mosaics. Klinefelter syndrome is defined as the male hypogonadism that occurs when there are two or more X chromosomes and two or more Y chromosomes. Compare the Difference Between Similar Terms. Karyotype of the Turner syndrome is monosomy of sex chromosome. Klinefelter syndrome is caused when a male baby is born with more than required or extra X chromosomes. When a girl is born with the different genetic condition than the normal one, it is called as Turner syndrome, in this, there is the loss of one of the sex chromosome (XO instead of XX). Advertisement - Continue Reading Below. Both males with Klinefelter syndrome and women with Triple X syndrome have an extra X chromosome; however women with Triple X syndrome do not also have a "Y" chromosome. This is the key difference between Klinefelter and Turner Syndrome. How to increase brand awareness through consistency; Dec. 11, 2020. What is Klinefelter Syndrome Turner syndrome, a condition that affects only females, results when one of the X chromosomes (sex chromosomes) is missing or partially missing. Klinefelter syndrome vs Turner syndrome. The main difference between Klinefelter and Turner Syndrome is that Klinefelter syndrome is a trisomy whereas Turner syndrome is a monosomy. Definition. Turner Syndrome In female infants, instead of an extra chromosome, Turner syndrome, named for the physician who discovered it in 1938, is caused by a lack of, or damage to, one of the pair of X chromosomes. Turner syndrome is the complete or partial monosomy of the X chromosome which is characterized primarily by the hypogonadism in phenotypic females. The early diagnosis of them can be helpful in treating the complications arising from the underlying disease. Klinefelter syndrome is defined as the male hypogonadism that occurs when there are two or more X chromosomes and two or more Y chromosomes. Turner syndrome and Klinefelter syndrome are similar in that they both affect the sexual chromosomes and the development of the gonads, or reproductive organs. Gene mutation and chromosomal mutations introduce alterations to the genetic material of a particular organism. Conclusion. Print. Turner syndrome is a monosomy, and it is most often associated with the karyotype 45, X. Klinefelter syndrome causes male hypogonadism. Down syndrome or Mongolism is autosomal disorder and turner and klinefelter's syndrome are sex chromosomal disorder caused due to non disjunction. Turner syndrome affects the development of the ovaries, while Klinefelter syndrome affects the development of the testes. Similarities Between Klinefelter and Turner Syndrome Dec. 15, 2020. Klinefelter syndrome is defined as the male hypogonadism that occurs when there are two or more X chromosomes and two or more Y chromosomes.  Klinefelter Syndrome vs Turner Syndrome, Difference Between Alzheimer’s and Dementia, Difference Between Gallstones and Kidney Stones, Difference Between Yeast Fungal and Bacterial Infections, Difference Between Dementia and Psychosis, Difference Between Insomnia and Sleep Apnea, Similarities Between Klinefelter and Turner Syndrome, Side by Side Comparison – Klinefelter vs Turner Syndrome in Tabular Form, non-disjunction during the meiotic division, Klinefelter and Turner Syndrome Differences, Klinefelter and Turner Syndrome Relationship, Difference Between Coronavirus and Cold Symptoms, Difference Between Coronavirus and Influenza, Difference Between Coronavirus and Covid 19, Difference Between Prone and Supine Position, Difference Between Substitutional and Interstitial Alloys, Difference Between Endocrine and Exocrine, Difference Between Philosophy and Psychology, Difference Between Galvanizing and Tinning, Difference Between Electroplating and Anodizing, Distinguish Between Chloroethane and Chlorobenzene, Difference Between Methotrexate and Methotrexate Sodium. The primary features are infertility and small poorly functioning testicles. These can be explained by saying that both the terms are problems related to the sex chromosomes, as in the earlier one there is lacking of one of the sex chromosomes and so-called as monosomy (2n-1), while the latter consist of the extra sex chromosome and so-called as trisomy (2n+1). It is due to monosomy (2n-1). Turner syndrome is also known as monosomy of the X chromosome. Answered on Jul 4, 2018. Summary. Both conditions can cause some behavioral concerns, learning difficulties, and taller stature. 3 doctors agree. See each disorder's website. Syndrome causes male hypogonadism male has 2 X chromosomes two or more chromosome... Early puberty gene Mutation and chromosomal mutations two X chromosomes the X chromosome, damages! Y chromosomes the two genetic disorders discussed here are extremely common conditions is far less than... 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